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250-403 Administration of Symantec(TM)(R) Management Platform 7.1

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Symantec Administration of Symantec(TM)(R) Management

EFI provides experienced govt to Board of administrators | killexams.com true Questions and Pass4sure dumps

Addition of Janice Chaffin Expands Board to Eight members

FREMONT, Calif., Nov. 08, 2018 (GLOBE NEWSWIRE) -- Electronics For Imaging, Inc. (EFII), a world chief in consumer-focused digital printing innovation, today announced the appointment of Janice Chaffin to its Board of directors.

Ms. Chaffin is an skilled know-how industry govt, that specialize in strategic advertising and international operations. She has held a few senior executive positions with Symantec organization, including serving as group president of its consumer company unit from 2007 to 2013. Ms. Chaffin furthermore serves on the boards of administrators of Nasdaq-traded corporations Synopsys, Inc. and PTC Inc. She is an Advisory Council member for Illuminate Ventures and a member of the Board of friends for the UCLA Anderson faculty of management. in the past she served on the boards of Informatica enterprise and exotic online game expertise, along with the working Committee of privately held Ancestry.com.  

Gill Cogan, Chairman of EFI’s Board of administrators, commented, “together with her tested learning in global advertising and marketing, approach, company construction, R&D administration and product development, Janice is a brilliant addition to the EFI board.”

“i am excited concerning the opportunities forward for EFI, and that i contemplate forward to contributing to the enterprise’s extend and strategic direction,” spoke of Ms. Chaffin.

Commenting on the appointment, EFI CEO invoice Muir noted, “Janice is a proven chief and innovator within the software and hardware industries. They loom ahead to benefiting from her skills as they proceed to develop their enterprise.”

earlier than main Symantec's purchaser industry unit, Ms. Chaffin served because the company's government vice president and chief advertising officer from 2006 to 2007, and as senior vice president and chief advertising and marketing officer from 2003 to 2006. earlier than becoming a member of Symantec, Ms. Chaffin worked for greater than twenty years at Hewlett-Packard industry in a lot of management and marketing management positions. Ms. Chaffin graduated summa cum laude from the college of California, San Diego, with a Bachelor of Arts diploma in Political Science, and earned a grasp of enterprise Administration from the college of California, la, where she became an Edward W. Carter Fellow.

About EFIEFI™ is a world technology enterprise, based mostly in Silicon Valley, and is leading the global transformation from analog to digital imaging. we're obsessed with fueling customer success with products that raise competitiveness and boost productiveness. To try this, they ameliorate step forward technologies for the manufacturing of signage, packaging, textiles, ceramic tiles, and customized documents, with a wide array of printers, inks, digital front ends, and a finished business and construction workflow suite that transforms and streamlines the entire production technique. (www.efi.com)

Contact assistance:

Investor RelationsJoAnn HorneMarket street Partnersir@efi.com415-445-3233


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Amit Yoran Interview: Cyberattacks concentrated on vital Infrastructure hold to breathe Addressed | killexams.com true Questions and Pass4sure dumps

lower back on June 25, 2018, the U.S. house of Representatives handed legislation aimed toward securing expertise used to vigour crucial infrastructure from cyberattacks.

in accordance with TheHill.com: “The bill provided by way of Rep. Don publisher 1st baron verulam (R-Neb.) would codify work the branch of fatherland security is presently doing to identify cyber threats to industrial wield techniques and mitigate them. Industrial wield techniques are used to run essential capabilities in the u.s., including the electric grid, water methods, and manufacturing flora.”

i will suppose of no one who can improved articulate their latest challenges and skills options related to critical infrastructure cybersecurity than existing Tenable CEO and Chairman Amit Yoran.

Yoran’s dazzling career  began on the united states armed forces Academy, and he was a founding member of the DoD’s united states computing device Emergency Readiness group (US CERT). He became co-founder and CEO of Riptech. When the enterprise turned into acquired by Symantec in August 2002, he became a Symantec vice president running world capabilities.

Yoran ran the department of spot of origin protection’s (DHS’s) countrywide Cyber safety Division (NCSD) and changed into the introductory director of the U.S.-CERT. Later he was the founder and CEO of NetWitness Corp in 2006, which turned into bought through RSA in 2011. Yoran became the senior vice president of RSA from 2011 to 2014 and president of RSA from October 2014 to December 2016.

He has been the chairman and CEO of Tenable community safety for the understanding that January 2017.

beyond his extraordinary resume, Yoran has seemed on many suitable television indicates relish PBS Frontline discussing cyberwar, and he has been quoted in lots of of media articles from Bloomberg to CNET and more.

which you can glean a sense of Amit Yoran’s talking style during this RSA presentation from last 12 months in the core East, which lays out some primary cyberprinciples and top priorities for the security road forward. He additionally articulates the ideas around cyberexposure in more depth.

I first met Amit returned in 2002, simply before Riptech was obtained by using Symantec. They had a number of mobilephone conversations through the years while i used to breathe Michigan executive CISO. He even got here as much as Lansing, Mich., to spend a day with me and my group to support us build their award-successful cybersecurity software.

What automatically impressed me about him (once I met him sixteen years in the past) turned into his ardour, accommodate and cutting-area protection capabilities, which is really an extraordinary mixture. He additionally provided international insights and international taste with large amounts of incident information that was beyond anything else that I had considered as much as that factor in my career. even so, he can still relate in a sort, mild and facile to recollect approach that doesn't talk over your head.

unique Interview Between Dan Lohrmann and Tenable Chairman and CEO Amit Yoran

Dan Lohrmann (DL): You were an exceedingly a hit safety chief for 2 a long time. How has the cyberthreat panorama advanced given that the 90s?

Amit Yoran (AY): As agencies increasingly weigh on expertise to control their statistics and everyday operations, they hold a involved merge of digital compute systems which characterize the concomitant assault surface. here, property and their linked vulnerabilities are normally increasing, contracting and evolving. The sheer breadth of concomitant cyberattacks capacity the stakes hold certainly not been better for agencies of outright sizes. Cybercriminals are invariably scanning for weakly defended systems and honing-in on high-price targets. This has made cybersecurity one of the most essential tenets in a firm’s structure. The Cyber exposure gap has made it tricky for an organization to breathe mindful its cyber risk at any given time. however bridging that hole is vital to managing and decreasing threats. without proper protections, agencies are susceptible to large-scale attacks relish that of the Equifax infraction of 2017, which left thousands and thousands affected. A Cyber publicity strategy gives reside visibility and makes cyber risk quantifiable.

DL: just recently, the administration published that Russia had leveraged a multi-yr campaign towards the energy grid and different features of valuable infrastructure within the u.s., what must breathe carried out by govt organizations in response?

AY: It’s no shock that their valuable infrastructure is a first-rate target of cyberattacks. Their national infrastructure — even if a indigenous water medication equipment, nuclear vigour reactor or the federally operated Hoover Dam — is reliant on interconnected expertise to convey essential public capabilities. The federal executive must deal with essential infrastructure the identical as a militia base or labeled suggestions. The Federal energy Regulatory commission (FERC) has proposed unique suggestions to offer protection to the power grid from cyberattacks, together with the essential Infrastructure coverage (CIP) Reliability common. here is a step in the redress route, but they will’t cease there. They want collective accountability amongst deepest entities and the federal govt to prioritize cybersecurity and change the status quo of vital infrastructure.

these days Tenable researchers institute a crucial far flung code execution vulnerability in Schneider electric’s InduSoft net Studio and InTouch machine version. because of this, a malicious actor could compromise and control the device and breathe able to execute lateral transfer. Tenable turned into in a position to become vigilant of this vulnerability via extensive Cyber exposure analysis and evaluation, featuring holistic visibility into how this vulnerability played into the larger gaps within the cyber landscape.

DL: How about the deepest-sector owners and operators? What actions are mandatory?

AY: lots of the assaults performed by way of cybercriminals are the outcome of commonly used, but unpatched vulnerabilities. corporations and the federal executive need to ensue first rate cyberhygiene, akin to preserving their systems, enforcing multi-factor authentication and using encryption. here is the foundation of sturdy cybersecurity programs. knowing their networks and invariably monitoring systems is important, certainly as the compute base alterations and the beset floor expands. there's an severe motivation from deepest sector homeowners and operators to stronger at ease their networks and notice these threats as the landscape evolves.

DL: Is a 'Cyber 9/11’ or a 'Cyber Pearl Harbor' probably? Inevitable? Why or why now not?

AY: recent assaults through nation-state actors on vital infrastructure and election techniques hold validated vulnerabilities and confirmed the cyberthreat is very precise. but they shouldn’t glean distracted by who is targeting their critical infrastructure, however how they’re doing it. The truth is that even subtle state actors are taking talents of frequent, unpatched vulnerabilities. it really is why focusing on the "who" is just a distraction. a tremendous assault on their critical infrastructure, or the know-how that maintains it running, may disrupt their economic methods, shut down cities, or leave hundreds of thousands without entry to clean water.

DL: What are the tremendous steps you’ve considered occurring in the public and personal sector? Who's doing issues prerogative related to cyberdefense? (Any case studies which you could point out?)

AY: I view the accelerated dialogue of cybersecurity within the C-suite, multiplied consciousness of the significance of cybersecurity, and the inclusion of cybersecurity in IT commercial enterprise solutions as exotic steps forward.

increased coordination between the common public and private sectors is furthermore a vital step within the redress direction. The NIST [National Institute of Standards and Technology] Framework exemplifies how the govt has labored with the inner most sector to set up guidelines on how organizations can enhance their standard cybersecurity posture. The framework is essential for helping to boost attention, enhance transparency and support the sharing of most fulfilling practices. The inordinate adoption rate among the private sector speaks to the a long way-attaining hold an consequence on of such initiatives beyond executive businesses. The passage and funding of the MGT [Modernizing Government Technology] Act was furthermore a benign step at the federal level. It authorized funding to upgrade IT tasks at businesses, and USDA, DOE and HUD simply acquired the first grants established by using the program.

Tenable has performed an critical position in several executive-subsidized initiatives. The protection counsel methods company (DISA) awarded Tenable the sure Compliance assessment respond (ACAS). ACAS ensures DISA compliance and makes it workable for the evaluation of DoD networks and linked IT systems against DoD requirements and identifies primary device vulnerabilities. moreover, Tenable complies with continuous Diagnostics and Mitigation (CDM) application necessities, enabling for seamless integration between executive corporations and corporations. via working side-through-aspect with the federal govt, Tenable has been capable of profile a strong partnership that ensures more suitable coverage.

DL: What unique and ingenious solutions will emerge over the subsequent year or two? Are there cyberinnovation stories that aren't getting enough consideration?

AY: businesses relish Tenable are constructing options to greater esteem agencies’ Cyber publicity, manage the elastic assault floor and further cloud security. companies are actually figuring out the value of continuous monitoring and are trying to find gear to stronger mitigate cyber risk. closing yr, they released Tenable.io, a cloud-based platform designed to give protection to any asset on any computing platform. Tenable.io has the skill to deliver overarching visibility into a company’s asset, including cellular gadgets and cloud infrastructure. Benchmarking Cyber publicity skill examining it across peer groups and industry. Tenable.io benchmarking records combines vulnerability intelligence and cybersecurity competencies. This enables for corporations to habits vital research, relish the time it takes to remediate vital exploitable vulnerabilities. These kinds of gear will continue emerging as their adversary becomes extra sophisticated.

DL: once I first met you, you had been running global managed protection features for Symantec (again in 2002). you've gotten additionally led numerous groups with very distinctive corporate innovations, what's different about Tenable? How has your position changed?

AY: Tenable’s strategy to cybersecurity is diverse from my previous experiences. The industry is assisting to trade the trade with Cyber publicity. As CEO, my function is to cheer lead the anxiety to evolve vulnerability administration into a next-technology enterprise solution that addresses a few of nowadays’s most simple safety challenges.

as the hazard panorama continues to extend and the nature of cyberattacks evolves, Tenable is focused on helping groups assess the most trustworthy strategy to investigate their cyber-risk. they now hold the skill to shift the conversation and build meaningful change towards a extra at ease future.

DL: I wish to thanks Amit for taking the time for this vital interview. Your industry abilities and notion leadership has enabled millions of individuals to greater give protection to their PCs, methods and firms capabilities towards cyberattacks. sustain up the exotic work!

Readers can comply with Amit Yoran on Twitter: @ayoran


250-403 Administration of Symantec(TM)(R) Management Platform 7.1

Study lead Prepared by Killexams.com Symantec Dumps Experts


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250-403 exam Dumps Source : Administration of Symantec(TM)(R) Management Platform 7.1

Test Code : 250-403
Test denomination : Administration of Symantec(TM)(R) Management Platform 7.1
Vendor denomination : Symantec
: 174 true Questions

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Administration of Symantec(TM)(R) Management Platform 7.1

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Emerging Categories of Disease in Advanced Prostate Cancer and Their Therapeutic Implications | killexams.com true questions and Pass4sure dumps

Prostate cancer represents a clinically and biologically heterogeneous disease entity, ranging from indolent localized tumors that finish not result in morbidity or mortality, to aggressive cancers that metastasize and ultimately lead to patient demise. In the localized disease setting, treatment guidelines (eg, National Comprehensive Cancer Network [NCCN], American Society of Clinical Oncology) provide guidance regarding risk factors for metastatic spread—including Gleason grade, serum prostate-specific antigen (PSA) level, and TNM stage—which can breathe used (along with disease characteristics and life expectancy) to determine whether definitive treatment or energetic surveillance is the more usurp strategy.[1,2] In the recurrent/metastatic setting, the “disease states model” of prostate cancer developed by the Prostate Cancer Working Group 3 (PCWG3) provides a useful framework for patient management. This model appropriately regards the development of metastases and castration resistance as distinct events in a patient’s disease course, with the various treatment options organized by disease state (Figure 1).[3]

Now that multiple therapies hold been approved by the US Food and Drug Administration for spend in metastatic castration-resistant prostate cancer, including abiraterone, enzalutamide, radium-223, sipuleucel-T, mitoxantrone, docetaxel, and cabazitaxel—with more treatments likely to follow—there is a clinical need to rush beyond the treatment framework provided by the NCCN and PCWG guidelines and to boost into better account the vast clinical and biological heterogeneity underpinning the varying treatment responses observed with these agents.[4-9] As this is done, distinct subsets of advanced prostate cancer are emerging that hold direct implications for patient management. In this article, they contemplate at both metastatic hormone-sensitive and metastatic castration-resistant disease, and they highlight several of the emerging categories of advanced prostate cancer that hold direct implications for patient management.

The classic disease states model regards metastatic hormone-sensitive prostate cancer as a sort of uniform disease entity, for which the standard of imbue has traditionally included primary androgen deprivation therapy (ADT) with a luteinizing hormone-releasing hormone (LHRH) analog, with or without the addition of an anti-androgen therapy. Primary ADT achieves objective and PSA responses in the vast majority of patients; however, the duration of response is variable, ranging from as short as 3 to 6 months to more than 5 years.[10]

Several clinical factors hold prognostic utility in predicting long-term outcomes in patients receiving ADT, including nadir PSA even after induction treatment, and extent of metastatic disease.[11,12] In one retrospective analysis of 1,395 patients enrolled in a prospective phase III study of intermittent vs continuous ADT in metastatic hormone-sensitive prostate cancer, a nadir PSA even < 0.2 ng/mL after 6 to 8 months of ADT was associated with a median overall survival (OS) of 75 months, compared with 13 months for those who had a PSA nadir > 4 ng/mL after induction treatment (P < .001).[11] Metastatic tumor burden, with extensive disease defined as four or more bone metastases (including one or more outside the axial column) and/or the presence of visceral metastases, has furthermore been shown to hold an impact on outcomes of primary ADT in the setting of metastatic hormone-sensitive disease. For example, in a previous randomized phase III study of bilateral orchiectomy with or without flutamide in patients with metastatic hormone-sensitive prostate cancer, those with extensive disease on scans had a significantly shorter survival than those with limited disease (median OS, 52.1 months vs 28.5 months; P < .05).[12]

Three phase III prospective clinical trials hold investigated whether the addition of docetaxel chemotherapy to ADT improves outcomes compared with ADT alone, with varying results (Table).[13-15] The Eastern Cooperative Oncology Group E3805 (CHAARTED) study prospectively stratified patients by limited vs extensive metastatic disease, as defined previously. In patients with extensive metastatic disease, there was a significant improvement in OS with the addition of docetaxel to ADT as compared with ADT alone (median OS, 51.2 months vs 34.4 months; P < .0001). In contrast, in those with a limited volume of disease, at the latest follow-up reported to date, there was no significant improvement in outcomes (median OS, 63.5 months vs not reached; hazard ratio [HR], 1.04; P = .86).[16]

In patients with hormone-sensitive prostate cancer and an extensive volume of metastatic disease, the magnitude of the survival benefit observed with the addition of docetaxel to primary ADT compares favorably with the survival advantage afforded by docetaxel (vs other chemotherapy regimens) in the metastatic castration-resistant setting, and suggests that earlier administration of chemotherapy translates to a greater survival advantage. This may in allotment reflect the fact that many patients with metastatic castration-resistant prostate cancer never receive chemotherapy during the course of their disease; indeed, among the patients randomized to ADT alone in E3805, of the 287 patients who had developed metastatic castration-resistant prostate cancer by the time of initial study publication, only 137 (48%) had received docetaxel chemotherapy.[13]

Two other phase III studies hold investigated the addition of docetaxel chemotherapy to ADT: the STAMPEDE and the GETUG-AFU 15 studies.[14,15] The STAMPEDE study population included an admixture of patients with locally advanced disease, patients with biochemically recurrent disease, and patients with metastatic disease; it demonstrated a significant improvement in OS with the addition of docetaxel in the overall study population, as well as in the subgroup of patients with metastatic disease (61% of patients) (Table). In contrast, GETUG-AFU 15 enrolled only patients with metastatic disease, and failed to demonstrate a survival benefit for the addition of docetaxel chemotherapy (median OS, 60.9 months vs 46.5 months for ADT alone; HR, 0.9; 95% CI, 0.7–1.2; P = .4). However, the GETUG-AFU 15 study was likely underpowered to detect OS differences. Neither GETUG-AFU 15 nor STAMPEDE prospectively stratified patients by extent of metastatic disease at the time of study entry, an valuable distinction between these two trials and the CHAARTED study.

Taken together, the results of these three studies hold transformed the management of metastatic hormone-sensitive prostate cancer, particularly in patients with extensive metastases on systemic imaging. In this setting, in patients fortunate to receive chemotherapy, the current standard of imbue is the administration of docetaxel chemotherapy for up to 6 cycles in conjunction with ADT. The management of limited-stage or oligometastatic disease is more individualized, and in the absence of prospective data confirming a survival benefit for the addition of docetaxel chemotherapy in this latter setting, it cannot breathe routinely recommended for outright patients and instead requires discussion with each individual patient.

Ongoing studies are investigating whether other combinatorial therapy may furthermore ameliorate treatment outcomes for patients with metastatic hormone-sensitive prostate cancer. Many studies are utilizing the paradigm followed by the phase III studies of docetaxel outlined previously, in which agents proven to hold a survival advantage in the metastatic castration-resistant setting are being evaluated in combination with ADT earlier in the disease course to investigate whether they hold a positive impact on long-term disease outcomes when used upfront. These studies include investigations of abiraterone, enzalutamide, and another second-generation androgen receptor antagonist (apalutamide), as well as bone-targeting agents, including radium-223—in combination with primary ADT. Over the next several years, the results of these studies may further change the treatment paradigm in the metastatic hormone-sensitive setting.

With esteem to the management of oligometastatic disease (variably defined as fewer than 3 to 5 metastatic lesions), one of the unanswered questions is the role of multimodality treatment (eg, radiation and/or surgical resection in combination with systemic ADT). The current standard of imbue is to selectively spend focally directed therapies palliatively at metastatic sites that are causing an undue symptom cross or that are institute in a critical location that may lead to significant morbidity (eg, a prostatic mass that is causing or that may antecedent urinary obstruction, or an epidural extension of tumor). In the absence of these types of metastatic lesions, definitive treatment of the primary tumor in the metastatic setting, as well as the application of focal therapy to metastatic lesions, has not been routinely performed.

Large retrospective analyses hold provided introductory evidence to suggest that there may breathe a therapeutic benefit to definitive treatment of the primary tumor in the setting of metastatic prostate cancer, even in the absence of a need for symptom palliation.[17] In one recent review of over 8,000 patients with M1 disease from the Surveillance, Epidemiology, and quit Results database, stratified on the basis of whether they did or did not receive local treatment, those at lower risk (≤ 40% risk) for cancer-specific mortality in the ensuing 3 years appeared to derive the most benefit from local treatment, after adjustment for other prognostic variables in the M1 setting.[17] The biological rationale for treatment of the primary tumor and/or focal treatment of metastatic sites includes: 1) decreased seeding of metastatic sites, 2) potentiation of immunologic response against the tumor, 3) synergistic activity with concurrent ADT, and 4) prevention of future comorbidity related to locoregional disease progression. The emerging clinical availability of more sensitive radiotracers for the detection of prostate cancer lesions, including those used in choline- and prostate-specific membrane antigen–based positron emission tomography imaging,[18,19] has provided further impetus for investigating treatment of the primary tumor and metastatic sites with multimodality therapy in patients with oligometastatic disease. At the current time, in the absence of prospective data, local treatment of an asymptomatic or minimally symptomatic primary tumor and/or focal treatment of asymptomatic oligometastatic sites of disease cannot breathe routinely recommended but is being actively investigated in multiple randomized studies. Whether the optimal management of oligometastatic disease with or without an untreated primary tumor differs in the hormone-sensitive vs the castration-resistant setting is likewise unknown but furthermore is currently being investigated in clinical studies.

References: 

1. National Comprehensive Cancer Network clinical practice guidelines in oncology—prostate cancer (version 2.2017). https://www.nccn.org/professionals/physician_gls/pdf/prostate.pdf. Accessed May 10, 2017.

2. Chen RC, Rumble RB, Loblaw DA, et al. energetic surveillance for the management of localized prostate cancer (Cancer imbue Ontario Guideline): American Society of Clinical Oncology clinical practice guideline endorsement. J Clin Oncol. 2016;34:2182-90.

3. Scher HI, Morris MJ, Stadler WM, et al. Trial design and objectives for castration-resistant prostate cancer: updated recommendations from the Prostate Cancer Clinical Trials Working Group 3. J Clin Oncol. 2016;34:1402-18.

4. Ryan CJ, Smith MR, de Bono JS, et al. Abiraterone in metastatic prostate cancer without previous chemotherapy. N Engl J Med. 2013;368:138-48.

5. Beer TM, Armstrong AJ, Rathkopf DE, et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N Engl J Med. 2014;371:424-33.

6. Tannock IF, de Wit R, Berry WR, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med. 2004;351:1502-12.

7. Parker C, Nilsson S, Heinrich D, et al. Alpha emitter radium-223 and survival in metastatic prostate cancer. N Engl J Med. 2013;369:213-23.

8. de Bono JS, Oudard S, Ozguroglu M, et al. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010;376:1147-54.

9. Small EJ, Schellhammer PF, Higano CS, et al. Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. J Clin Oncol. 2006;24:3089-94.

10. Hussain M, Tangen CM, Berry DL, et al. Intermittent versus continuous androgen deprivation in prostate cancer. N Engl J Med. 2013;368:1314-25.

11. Hussain M, Tangen CM, Higano C, et al. Absolute prostate-specific antigen value after androgen deprivation is a strong independent predictor of survival in unique metastatic prostate cancer: data from Southwest Oncology Group Trial 9346 (INT-0162). J Clin Oncol. 2006;24:3984-90.

12. Eisenberger MA, Blumenstein BA, Crawford ED, et al. Bilateral orchiectomy with or without flutamide for metastatic prostate cancer. N Engl J Med. 1998;339:1036-42.

13. Sweeney CJ, Chen YH, Carducci M, et al. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. N Engl J Med. 2015;373:737-46.

14. Gravis G, Fizazi K, Joly F, et al. Androgen-deprivation therapy alone or with docetaxel in non-castrate metastatic prostate cancer (GETUG-AFU 15): a randomised, open-label, phase 3 trial. Lancet Oncol. 2013;14:149-58.

15. James ND, Sydes MR, Clarke NW, et al. Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial. Lancet. 2016;387:1163-77.

16. Sweeney C, Chen YH, Liu G, et al. Long term efficacy and QOL data of chemohormonal therapy in low and lofty volume hormone naïve metastatic prostate cancer: E3805 CHAARTED trial. Ann Oncol. 2016;27(suppl 6):720PD.

17. Fossati N, Trinh QD, Sammon J, et al. Identifying optimal candidates for local treatment of the primary tumor among patients diagnosed with metastatic prostate cancer: a SEER-based study. Eur Urol. 2015;67:3-6.

18. Koulikov V, Barnes S, Even-Sapir E. 68Ga-PSMA PET-CT in patients with newly diagnosed high-risk prostate cancer. J Nucl Med. 2016;57(suppl 2):1540.

19. Giovacchini G, Picchio M, Garcia-Parra R, et al. 11C-choline PET/CT predicts prostate cancer–specific survival in patients with biochemical failure during androgen-deprivation therapy. J Nucl Med. 2014;55:233-41.

20. Buttigliero C, Tucci M, Bertaglia V, et al. Understanding and overcoming the mechanisms of primary and acquired resistance to abiraterone and enzalutamide in castration resistant prostate cancer. Cancer Treat Rev. 2015;41:884-92.

21. Noonan KL, North S, Bitting RL, et al. Clinical activity of abiraterone acetate in patients with metastatic castration-resistant prostate cancer progressing after enzalutamide. Ann Oncol. 2013;24:1802-7.

22. Azad AA, Eigl BJ, Murray RN, et al. Efficacy of enzalutamide following abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer patients. Eur Urol. 2015;67:23-9.

23. Schrader AJ, Boegemann M, Ohlmann CH, et al. Enzalutamide in castration-resistant prostate cancer patients progressing after docetaxel and abiraterone. Eur Urol. 2014;65:30-6.

24. Bianchini D, Lorente D, Rodriguez-Vida A, et al. Antitumour activity of enzalutamide (MDV3100) in patients with metastatic castration-resistant prostate cancer (CRPC) pre-treated with docetaxel and abiraterone. Eur J Cancer. 2014;50:78-84.

25. Antonarakis ES, Lu C, Wang H, et al. AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N Engl J Med. 2014;371:1028-38.

26. Schweizer MT, Antonarakis ES, Wang H, et al. consequence of bipolar androgen therapy for asymptomatic men with castration-resistant prostate cancer: results from a pilot clinical study. Sci Transl Med. 2015;7:269ra2.

27. Smith DC, Redman BG, Flaherty LE, et al. A phase II trial of oral diethylstilbestrol as a second-line hormonal agent in advanced prostate cancer. Urology. 1998;52:257-60.

28. Shamash J, Powles T, Sarker SJ, et al. A multi-centre randomised phase III trial of dexamethasone vs dexamethasone and diethylstilbestrol in castration-resistant prostate cancer: immediate vs deferred diethylstilbestrol. Br J Cancer. 2011;104:620-8.

29. Antonarakis ES, Chandhasin C, Osbourne E, et al. Targeting the N-terminal domain of the androgen receptor: a unique approach for the treatment of advanced prostate cancer. Oncologist. 2016;21:1427-35.

30. Alanee S, Moore A, Nutt M, et al. concomitant incidence and mortality rates of neuroendocrine prostate cancer. Anticancer Res. 2015;35:4145-50.

31. Small EJ, Huang J, Youngren J, et al. Characterization of neuroendocrine prostate cancer in patients with metastatic castration resistant prostate cancer resistant to abiraterone or enzalutamide: introductory results from the SU2C/PCF/AACR West Coast Prostate Cancer Dream Team. J Clin Oncol. 2015;33(suppl):abstr 5003.

32. Aparicio AM, Harzstark AL, Corn PG, et al. Platinum-based chemotherapy for variant castrate-resistant prostate cancer. Clin Cancer Res. 2013;19:3621-30.

33. Lord R, Nair S, Schache A, et al. Low dose metronomic oral cyclophosphamide for hormone resistant prostate cancer: a phase II study. J Urol. 2007;177:2136-40.

34. Berry W, Dakhil S, Modiano M, et al. phase III study of mitoxantrone plus low dose prednisone versus low dose prednisone alone in patients with asymptomatic hormone refractory prostate cancer. J Urol. 2002;168:2439-43.

35. Robinson D, Van Allen EM, Wu YM, et al. Integrative clinical genomics of advanced prostate cancer. Cell. 2015;161:1215-28.

36. Mateo J, Carreira S, Sandhu S, et al. DNA-repair defects and olaparib in metastatic prostate cancer. N Engl J Med. 2015;373:1697-708.

37. Lord CJ, Ashworth A. BRCAness revisited. Nat Rev Cancer. 2016;16:110-20.

38. Pritchard CC, Mateo J, Walsh MF, et al. Inherited DNA-repair gene mutations in men with metastatic prostate cancer. N Engl J Med. 2016;375:443-53.


Spirent Communications' (SPMYY) CEO Eric Hutchinson on Q2 2017 Results - Earnings convoke Transcript | killexams.com true questions and Pass4sure dumps

No result found, try unique keyword!So, they can view here the increased revenue of the identical even of product development expenditure and they finish continue to focus their R&D activity to match key ... and further develop their key account managem...

101 Statutory Changes | killexams.com true questions and Pass4sure dumps

According to at least one hearsay report, members of Congress are working toward a unique patent reform bill on subject matter eligibility – likely partially following the models prepared by the IPO and pushed by Dave Kappos (among others).  There is some chance that it will breathe introduced this month.

I previously discussed the IPO Proposal:

Eligibility: Explaining the IPO Legislative Proposal



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